Journal: Journal of the Endocrine Society
Article Title: Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women
doi: 10.1210/js.2018-00151
Figure Lengend Snippet: OGTT study insulinogenic index and its relationship to HbA1c by subject. Panels A and B plot the insulinogenic index, an indicator of first-phase insulin release, which is calculated as Δ insulin from 0 to 30 minutes)/( Δ glucose from 0 to 30 minutes) ( Δ I 0-30 / Δ G 0-30 ). Panels C and D plot the equivalent index using C-peptide ( Δ CP 0-30 / Δ G 0-30 ). Panels A and C show two versions of the insulinogenic index, Δ I 0-30 / Δ G 0-30 and Δ CP 0-30 / Δ G 0-30 , by session (control, BPA). Panels B and D show the percentage change in outcomes between the BPA and control sessions, plotted against HbA1c, where the percentage change in the insulinogenic index or the C-peptide equivalent was calculated as the percentage change in outcome (% Δ X) between BPA and control sessions = 100% × (X BPA – X control )/X control . HbA1c was measured from the baseline blood draw of each subject’s first visit. A linear regression line is included in the scatterplots with shaded 95% CI. The correlations of these variables with HbA1c are (B) Δ I 0-30 / Δ G 0-30 Spearman = 0.92, P = 0.0014 and (D) Δ CP 0-30 / Δ G 0-30 Pearson = 0.97, P = 0.0001. Points are labeled with the subject IDs, which correspond to the rank ordering of their HbA1c (M1 to M8 = low to high). Shapiro-Wilk normality test was used to select Pearson or Spearman correlations, using P value cutoff of >0.3 as “normal.”
Article Snippet: Serum was analyzed at the University of Missouri Diabetes Diagnostic Laboratory for hemoglobin A1c (HbA1c) (using the Tosoh G8 variant mode ion-exchange HPLC method; Tosoh Biosciences, San Francisco, CA).
Techniques: Control, Labeling
